l-Arginine is the only precusor to nitric oxide in the body. You can search nobel prize for nitric oxide and find all kinds of info. Here are just a few of the links I was able to find. Any time you increase circulation you will reap the benefits. Human Growth Hormone is also a result of l-Arginine in the body and as the patent states RG9m2 helps the body to release its own HGH.
J Clin Endocrinol Metab. 2006 Feb;91(2):477-84. Epub 2005 Dec 6.
[Nobel prize in Medicine and Physiology 1998 for t...[Ned Tijdschr Geneeskd. 1998] - PubMed Result
l-Arginine is a precursor of nitric oxide, which causes blood vessel relaxation (vasodilation). Preliminary evidence suggests that arginine may be useful in the treatment of medical conditions that are improved by vasodilation, such as angina, atherosclerosis, coronary artery disease, erectile dysfunction, heart failure, intermittent claudication/peripheral vascular disease, and vascular headache. Arginine also stimulates protein synthesis and has been studied for wound healing, bodybuilding, enhancement of sperm production (spermatogenesis), and prevention of wasting in people with critical illness.
Arginine (L-arginine) - MayoClinic.com Probing Erectile Function: S-(2-Boronoethyl)-L-Cysteine Binds to Arginase as a Transition State Analogue and Enhances Smooth Muscle Relaxation in Human Penile Corpus Cavernosum,
CONCLUSIONS: This pilot study shows that the on-demand oral administration of the L-arginine glutamate 6g and 6 mg yohimbine combination is effective in improving erectile function in patients with mild to moderate ED. It appears to be a promising addition to first-line therapy for ED.PMID: 12074777 [PubMed - indexed for MEDLINE]
Efficacy and safety of a novel combination of L-ar...[Eur Urol. 2002] - PubMed Result Oral L-arginine improves cardiovascular function and reduces myocardial ischemia in coronary artery patients PUBLISHED CLINICAL ABSTRACT BELOW
Tapiero H, Mathe G, Couvreur P, Tew KD. Faculte de pharmacie, universite de Paris, CNRS UMR 8612, 5, rue Jean-Baptiste-Clement, 94200 Chatenay-Malabry, France. haimtapiero@aol.com L-Arginine (Arg) is classified as an essential amino acid for birds, carnivores and young mammals and a conditionally essential amino acid for adults. It is converted by arginase to L-ornithine, a precursor of polyamines and urea, which is important in the urea cycle. Arg serves as a precursor for creatine, which plays an essential role in the energy metabolism of muscle, nerve and testis and accounts for Arg catabolism and for the synthesis of agmatine and proteins. Via its ability to increase growth hormone secretion it influences immune function. Depending on nutritional status and developmental stage, normal plasma Arg concentrations in humans and animals range from 95 to 250 micromol/l. Systemic or oral Arg administration has been shown to improve cardiovascular function and reduce myocardial ischemia in coronary artery disease patients. It reduces blood pressure and renal vascular resistance in essential hypertensive patients with normal or insufficient renal function. Although Arg plasma concentrations are not altered in hypercholesterolemic individuals, oral or intravenous Arg administration can reverse endothelial dysfunction in hypercholesterolemic patients and in cigarette smokers. The main importance of Arg is attributed to its role as a precursor for the synthesis of nitric oxide (NO), a free radical molecule that is synthesized in all mammalian cells from L-Arg by NO synthase (NOS). NO appears to be a major form of the endothelium-derived relaxing factor (EDRF). NO and EDRF share similar chemical and pharmacological properties and are derived from the oxidation of a terminal guanidine group of L-Arg. Various mechanisms have been implicated in the defect in vascular relaxation. These include, increased diffusional barrier for NO, L-Arg depletion, altered levels of reactive oxygen, inactivation of NO by superoxide anions (O2-). The independent reactions of O2-, NO and their reaction yielding peroxynitrite are critical in the initiation and maintenance of the atherosclerotic state and contribute to the defect in vasorelaxation. NO also plays a role as a neurotransmitter, mediator of immune response and as signaling molecule. The NO synthesized by iNOS in macrophages contributes to their cytotoxic activity against tumor cells, bacteria and protozoa. ClinicalAbstractSamples Human Growth Hormone Human Growth Hormone and L-Arginine Growth Hormone Secretagogue Supplements: Do They Reverse Aging in Patients Over Age 40? | Dynamic Chiropractic | Find Articles at BNET.com