[8 x 8]

greetings.
if anyone knows the size of the tadalafil(liquid cialis) molecule, and whether or not a topical application inside the urethra, using no carrier, is:
1. possible
2. effective
3. if localized absorption is strong, how much to reduce dose by?
4. any side effects of this application?

if topical application of liquid cialis is not possible or has too many side effects this way:
1. can it be topically applied, with or w/o carrier, to the glans or shaft skin?
2. if a carrier is required for this method, which carrier is best?

thank you for any answers, questions, or comments.

[thesheet247]

Before I go and retrieve the answer to your question, I'd like to ask why you would choose to administer the chemical tadalafil citrate as a topical when it can simply be taken orally?

[JonPop]

Why would you risk an infection/severe irritation by sticking some unknown product into your urethra through your meatus?

[growing4her]

Off topic Jp but my wife saw a guy with a spoon shoved up there , then a guy with a pencil .

[JonPop]

Is your wife a nurse?

[growing4her]

Yes . I ask her alot of questions about this stuff , she understands the human body extremely well

[eompow]

Originally Posted by growing4her

Off topic Jp but my wife saw a guy with a spoon shoved up there , then a guy with a pencil .

In the ER truth is stranger than fiction.

[8 x 8]

Originally Posted by thesheet247

Before I go and retrieve the answer to your question, I'd like to ask why you would choose to administer the chemical tadalafil citrate as a topical when it can simply be taken orally?

1. To keep the effects as localized as possible.
in addition to being a PDE5 blocker, tadalafil is a quasi-PDE11 blocker, and while there are no known side effects for this, PDE11 is involved in the kidneys, skeletal muscle, and other organs.
i'd rather keep my research as localized as possible.

Other unintended benefits might possibly be:
2. Faster action by the tadalafil on the glans and corpus (5 minutes instead of 45min)
3. Lower mg dose needed to achieve what 10-15mg can achieve thru an oral dose ($ savings)

That said, if their are serious drawbacks or irritation/contraindications to this method of urethral application, what carrier is needed to apply liquid cialis transdermally thru the glans or shaft skin? Again, thanks for any answers, discusiion, questions, or comments.

[8 x 8]

Transdermal Delivery of Tadalafil. I. Effect of Vehicles on Skin Permeation; Drug Development and Industrial Pharmacy - 35(3):Pages 329-336 - Informa Healthcare

apparently, propolene glycol is a good method, but i do not have a prescription to this site, and would like to see a full text version for details.
If anyone can help with this, please let me know. thanks.