LoginJoin For Free

PEGym

Get the Penis YOU WANT

Main menu

Skip to primary content
Skip to secondary content
  • Articles
  • Exercises
  • Products
  • Guides
  • Toolbox
  • Forums

Secondary menu

Skip to primary content
Skip to secondary content
  • Penis Exercises
  • Penis Enlargement
  • Jelqing
  • Kegel Exercises
  • Penis Pumps
  • Penis Extenders
  • Erectile Dysfunction
  • Premature Ejaculation
  • Penis Forums
    • START HERE!
    • FAQ
    • Guidelines
    • My Posts
    • My Threads
    • Quick Links
      • Mark Forums Read
      • View Site Leaders
  • Groups
  • Photos
  • What's New?
  • Advanced Search
  • Home
  • Forum
  • PEGym
  • PE Theory & Science Forum
  • Chemical PE
  • Anyone using agamatine over L-Arginine??

  1. Enhance Your Penis in the Shower



    1. Bathmate is the world's #1 selling pump! It's safer than air pumps and the most comfortable pump on the market! Plus, the Bathmate is so easy to use! Simply use it while you go about your normal bathing routine!

      Get REAL results! ORDER NOW!

Results 1 to 2 of 2
Like Tree1Likes
  • Top
  • All

Thread: Anyone using agamatine over L-Arginine??

  • LinkBack
    • LinkBack URL LinkBack URL
    • About LinkBacks About LinkBacks
    •  
    • Bookmark & Share
    • Digg this Thread!
    • Add Thread to del.icio.us
    • Bookmark in Technorati
    • Tweet this thread
  • Thread Tools
    • Show Printable Version
  • Display
    • Switch to Hybrid Mode
    • Switch to Threaded Mode
  1. 09-10-2015 #1
    Armanilexi
    Armanilexi is offline
    Junior Member
    Join Date
    Sep 2015
    Posts
    18
    I've been hearing some good things and reading even better things about agamatine and thinking about using that instead of arginine. I was curious to know if anyone else has tried it or currently using it and what results have they had
    • Share
      • Share this post on
      • Digg
      • Del.icio.us
      • Technorati
      • Twitter
    Reply With Quote Reply With Quote

  2. 09-10-2015 #2
    corageon
    corageon is offline
    Banned
    Join Date
    Nov 2013
    Location
    New York
    Posts
    2,750
    Agmatine is over-rated IMO - it also can actually reduce nitric oxide..it basically acts like Clonidine which is an anti-hypertensive/anti-anxiety drug.

    Neuropharmacology. 2003 Sep;45(4):534-42.Agmatine exerts anticonvulsant effect in mice: modulation by alpha 2-adrenoceptors and nitric oxide.

    Demehri S1, Homayoun H, Honar H, Riazi K, Vafaie K, Roushanzamir F, Dehpour AR.
    Author information



    Abstract

    The effect of agmatine, an endogenous polyamine metabolite, on seizure susceptibility was investigated in mice. Acute intraperitoneal administration of agmatine (5, 10, 20, 40 mg/kg) had a significant and dose-dependent inhibitory effect on pentylenetetrazole (PTZ)-induced seizures. The peak of this anticonvulsant effect was 45 min after agmatine administration. We further investigated the possible involvement of the alpha(2)-adrenoceptors and L-arginine/NO pathway in this effect of agmatine. The alpha(2)-adrenoceptor antagonist, yohimbine (0.5-2 mg/kg), induced a dose-dependent blockade of the anticonvulsant effect of agmatine. The nitric oxide synthase (NOS) substrate, L-arginine (60 mg/kg), inhibited the anticonvulsant property of agmatine and this effect was significantly reversed by NOS inhibitor N(G)-nitro-L-arginine (L-NAME, 30 mg/kg), implying an NO-dependent mechanism for L-arginine effect. We further examined a possible additive effect between agmatine (1 or 5 mg/kg) and L-NAME (10 mg/kg). The combination of L-NAME (10 mg/kg) with agmatine (5 but not 1 mg/kg) induced a significantly higher level of seizure protection as compared with each drug alone. Moreover, a combination of lower doses of yohimbine (0.5 mg/kg) and L-arginine (30 mg/kg) also significantly decreased the anticonvulsant effect of agmatine. In conclusion, the present data suggest that agmatine may be of potential use in seizure treatment.


    PMID:12907314[PubMed - indexed for MEDLINE]

    Neurochem Int. 1997 Jan;30(1):37-45.Central cardiovascular actions of agmatine, a putative clonidine-displacing substance, in conscious rabbits.
    Head GA1, Chan CK, Godwin SJ.
    Author information
    Abstract
    Agmatine, an endogenous clonidine-displacing substance, has been shown to have an affinity for both alpha 2-adrenoceptors and imidazoline receptors (IR). In conscious rabbits, we have examined the cardiovascular effects of agmatine and its interaction with clonidine, a presumed agonist and 2-methoxyidazoxan, an antagonist at alpha 2-adrenoceptors. We have also examined the effect of agmatine on agents having high affinity for I1-imidazoline receptors namely moxonidine (agonist) and efaroxan (antagonist). Initial dose-response studies showed that agmatine administered in low doses (0.01-10 micrograms/kg) into the fourth ventricle did not change mean arterial pressure but did produce a dose-dependent bradycardia (maximum -16 +/- 3 beats/min). A higher dose of 100 micrograms/kg produced an adverse reaction in the conscious animals accompanied by a marked increase in mean arterial pressure and a reversal of the bradycardia. This is in contrast to the effects of fourth ventricular clonidine and moxonidine, which caused a dose-dependent fall in both mean arterial pressure and heart rate. Agmatine when administered at the highest well-tolerated dose of 10 micrograms/kg did not further alter the clonidine-induced hypotension but produced a greater bradycardia (-12 +/- 4 beats/min clonidine; -29 +/- 4 beats/min clonidine plus agmatine; p < 0.05). Similarly, the hypotension induced by moxonidine was not altered by agmatine but heart rate was reduced after the addition of agmatine (p < 0.01). Efaroxan and 2-methoxy-idazoxan, at doses which produced no effects when given alone, similarly reversed the fall in heart rate elicited by agmatine and caused a small but significant rise in mean arterial pressure. We have previously shown that the doses of these antagonists used in this study produce an equal reversal of the bradycardia induced by fourth ventricular alpha-methyldopa (alpha 2-adrenoceptor agonist) and clonidine and hence have similar alpha 2-adrenoceptor blocking effects. Our results show that agmatine produces bradycardia as does moxonidine and clonidine but does not mimic or block the hypotensive responses to these agents. These findings do not support the hypothesis that agmatine is an endogenous ligand for IR. However, the bradycardia induced by agmatine may be mediated via alpha 2-adrenoceptors since it was equally blocked by efaroxan and 2-methoxy-idazoxan. Thus while alpha 2-adrenoceptor actions of agmatine on heart rate are evident at relatively low doses, the reason for the lack of alpha 2-adrenoceptor mediated hypotension is not known.
    PMID: 9116586 [PubMed - indexed for MEDLINE]
    • Share
      • Share this post on
      • Digg
      • Del.icio.us
      • Technorati
      • Twitter
    Reply With Quote Reply With Quote

« Previous Thread | Next Thread »
  • Join Now for Free

    The Penis Gym community makes it easy to get personal advice, ask questions, stay motivated with like-minded men, start your own PE blog, and much more.


  • Latest Posts
    • DeMi-GoD

      Hi. Let me just start off by...

      Penis pump before sex experience....
      6 Minutes Ago
    • Toolbuilder

      I wasn't aware that you could...

      Going to start using Bathmate for...
      1 Hour Ago
    • notmainstream

      Yeah im aware. Just wanted to...

      100 reps with more than 2 days of...
      2 Hours Ago
    • moodymistery

      DAYS 17, 18, 19 (rest), 20...

      The book of Moody
      2 Hours Ago
    • Cunny Linguist

      You can use the thumb screws...

      Quick Extender Pro Log
      2 Hours Ago
    • 83show

      Short question. Pumping...

      Double my size ??
      4 Hours Ago
    • jibeyx

      Just asking, like if i did a...

      is there such a thing as too much...
      4 Hours Ago
    • VaultPic

      (04/14/21) 15 min Warm up...

      VP's New Log
      5 Hours Ago
    • Pegasus

      Yes . Now central deposited...

      fat pad and visceral fat
      6 Hours Ago
    • ehlolol

      lol

      Clamping Q & A
      6 Hours Ago
  • Latest Group Post
    • fams33
      Looking for a help to cure ED and...

      Hi friends, I am 31 year old. I...

      Posted By Pegasus (1 replies)
      1 Week Ago

    Mobile Site
  • Contact Us
  • Penis Forums
  • Archive
  • Privacy Statement
  • Terms of Service
  • Top
All times are GMT -5. The time now is 12:21 AM.
Powered by vBulletin® Version 4.2.3
Copyright © 2021 vBulletin Solutions, Inc. All rights reserved.
Search Engine Optimization by vBSEO 3.6.1 ©2011, Crawlability, Inc.