Urethral/topical tadalafil(liquid cialis) application?

[8 x 8 Member Find all posts View Profile Close 8 x 8]

greetings.
if anyone knows the size of the tadalafil(liquid cialis) molecule, and whether or not a topical application inside the urethra, using no carrier, is:
1. possible
2. effective
3. if localized absorption is strong, how much to reduce dose by?
4. any side effects of this application?

if topical application of liquid cialis is not possible or has too many side effects this way:
1. can it be topically applied, with or w/o carrier, to the glans or shaft skin?
2. if a carrier is required for this method, which carrier is best?

thank you for any answers, questions, or comments.

[thesheet247 Junior Member Find all posts View Profile Close thesheet247]

I may be able to answer your question...

Before I go and retrieve the answer to your question, I'd like to ask why you would choose to administer the chemical tadalafil citrate as a topical when it can simply be taken orally?

[JonPop Retired Sr. Administrator PEGym Hero Find all posts View Profile Close JonPop]

Why would you risk an infection/severe irritation by sticking some unknown product into your urethra through your meatus?

[growing4her Senior Member Find all posts View Profile Close growing4her]

Off topic Jp but my wife saw a guy with a spoon shoved up there , then a guy with a pencil .

[JonPop Retired Sr. Administrator PEGym Hero Find all posts View Profile Close JonPop]

Is your wife a nurse?

[growing4her Senior Member Find all posts View Profile Close growing4her]

Yes . I ask her alot of questions about this stuff , she understands the human body extremely well

[eompow Senior Member Find all posts View Profile Close eompow]

Off topic Jp but my wife saw a guy with a spoon shoved up there , then a guy with a pencil .

In the ER truth is stranger than fiction.

[8 x 8 Member Find all posts View Profile Close 8 x 8]

Before I go and retrieve the answer to your question, I'd like to ask why you would choose to administer the chemical tadalafil citrate as a topical when it can simply be taken orally?

1. To keep the effects as localized as possible.
in addition to being a PDE5 blocker, tadalafil is a quasi-PDE11 blocker, and while there are no known side effects for this, PDE11 is involved in the kidneys, skeletal muscle, and other organs.
i'd rather keep my research as localized as possible.

Other unintended benefits might possibly be:
2. Faster action by the tadalafil on the glans and corpus (5 minutes instead of 45min)
3. Lower mg dose needed to achieve what 10-15mg can achieve thru an oral dose ($ savings)

That said, if their are serious drawbacks or irritation/contraindications to this method of urethral application, what carrier is needed to apply liquid cialis transdermally thru the glans or shaft skin? Again, thanks for any answers, discusiion, questions, or comments.

[8 x 8 Member Find all posts View Profile Close 8 x 8]

Transdermal Delivery of Tadalafil. I. Effect of Vehicles on Skin Permeation; Drug Development and Industrial Pharmacy - 35(3):Pages 329-336 - Informa Healthcare

apparently, propolene glycol is a good method, but i do not have a prescription to this site, and would like to see a full text version for details.
If anyone can help with this, please let me know. thanks.

[8 x 8 Member Find all posts View Profile Close 8 x 8]

If anyone has any additional information on transdermal or urethral application of Cialis, please post it here, yes bump.

[8 x 8 Member Find all posts View Profile Close 8 x 8]

Well, I am considering ordering the powdered Tadalafil for researching this urethral/topical application style. After having found ChemOne's Liquid tadalafil to have good quality, will I be satisfied with the Powdered tadalafil from Elitenet pharm? Or does someone have a better source for the purest powdered tadalafil ?

[Jackxxx Banned Find all posts View Profile Close Jackxxx]

Sounds interesting. Good luck! Instead of buying bulk powder, you can just smash a generic tab and mix it with the carrier. Same shit. What are you planning to try as a carrier?

[Jackxxx Banned Find all posts View Profile Close Jackxxx]

Hey 8x8, I am working on a highly advanced and effective transdermal carrier. It works specifically for chemicals with a molecular weight of 500 or less. 300 or less ideal. Tadalafil has a molecular weight of 389.41, so it would work fine. However, the pure raw tadalafil powder would be better. Original Cialis prescription is mixed with several inactive ingredients.

For the topical solution, send me a PM for more info. Perhaps this thread should be moved to the science forum? A mod can decide that.

[JonPop Retired Sr. Administrator PEGym Hero Find all posts View Profile Close JonPop]

Jack. I hope for your sake, (liability issues) that you aren't setting up your own little clinic on our site via PM's. (jP

[Jackxxx Banned Find all posts View Profile Close Jackxxx]

Jack. I hope for your sake, (liability issues) that you aren't setting up your own little clinic on our site via PM's. (jP

LOL. No. I don't have time for that. The only reason I share some information via PM, is because as some mods have stated, some information can be misused by young or unexperienced people and harm themselves. What I do and try, is a product of deep research, study, and personal experience. Is not something that anybody can just copy and paste and try it.