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  • Sudden loss of erection during sex and ever after

    Hi,

    Glad I can share that with someone and I'll go straight to the point.

    I'm 32y and had PE for life but never ever had any EQ problems. I usually get erection easy, just touching my wife worked before. Because of my PE I thought that 5HTP might have a a positive effect as SSRIs worked really well. I started taking 100mg 5HTP daily in the morning and then for a week or two I was taking it twice a day. I was also taking Maca root 1g once per day. I haven't abused the supplements, probably I was taking them for 2/3 weeks. In the meanwhile I took on few occasion Priligy (30mg). That drug works the same way as majority of SSRI but starts working almost immediately and the side effects are less. So from 2mins I was able to last more than 20 mins.

    Maybe it was third time I took Priligy and everything was perfect. While having sex in the middle of the act I suddenly lost my erection and couldn't regain it, without a reason. It was like someone pressed a button and switch it off. Since then (almost two months) I don't get random erections at all, neither night or morning ones. I feel difficulty getting aroused, EQ loss and maintaining erection, no pains or what so ever. I stopped 5HTP and Maca immediately. Now I'm very confused on what the hell happened. I can remember I had similar periods before - lack of libido and maybe it's just temporarily OR (worse) 5HTP and Priligy messed up my brain. I already read some horror stories about 5HTP but again, I didn't abuse them and I was taking 5HTP for 2-3 weeks only and had Priligy (30mg) 2-3 times in the meanwhile. It's even hard to sustain erection since then and I NEVER had this problem before, it's like my sensitivity is gone or something similar. I tried watching porn or get aroused before edging but it's really hard it's like my brain doesn't accept it. I had sex few times with my wife but it was hard to get aroused and get a good EQ. You know when you start thinking about sex or imagining stuff it usually works, well it doesn't work anymore for me.

    The other change in my lifestyle was that I started weight lifting and bulking, gained almost 8kg for 2 months.

    I had an Utrasound examination of my testicles and everything is fine. I'm waiting for my blood and urine tests now.

    Has anyone experienced something like that or do you have any idea. I got used to PE but that really scares me.

    I'll appreciate your comments. Thanks!

    Regards

  • #2
    You dulled out your nerves with excessive serotonin increases...thus producing a form of PSSD (Post-SSRI-Sexual Dysfunction), in which case...even though the initial serotonin increase helped your P.E - you crossed that fine line where now your sexual nerves are being rapidly depleted. So now unfortunately, you have to work backwards and start antagonizing / blocking serotonergic activity, and increasing dopamine and histamine to get the nerves going again.

    Get bloodwork done just in case, a full hormone panel if possible...but it definitely seems to give the air of serotonergic issues....seeing as your other aspects of health are fine.

    Folic acid, l-histidine, l-arginine, shilajit, mucuna pruriens / L-Dopa and berberine would be my recommendations...depending on how bad it is..but make sure you didn't cause some sort of additional vascular issue in the process!

    Comment


    • #3
      Corageon, thanks mate, that was fast! Please do tell me that's reversible !?

      I completely agree but you know when you are desperate you are doing stupid things, I don't know why I was so desperate to increase my serotonin so much. I read that taking SSRI with other types (MAOI) could cause serious consequences with potential lethal end or at least get a Serotonin Syndrome. Going through the symptoms I don't think I have SS.

      Few years back I remember I took Saroxat and had an amazing effect, fortunately I didn't got that PSSD effect back then. Do you think that by just taking Priligy few times along with 5HTP could cause the same effect as PSSD ?

      I've done blood test including sex hormones, cholesterol and urine. So hopefully they will give some sign or direction.

      Thanks once again.

      Comment


      • #4
        Originally posted by Neuromancer View Post
        Corageon, thanks mate, that was fast! Please do tell me that's reversible !?

        I completely agree but you know when you are desperate you are doing stupid things, I don't know why I was so desperate to increase my serotonin so much. I read that taking SSRI with other types (MAOI) could cause serious consequences with potential lethal end or at least get a Serotonin Syndrome. Going through the symptoms I don't think I have SS.

        Few years back I remember I took Saroxat and had an amazing effect, fortunately I didn't got that PSSD effect back then. Do you think that by just taking Priligy few times along with 5HTP could cause the same effect as PSSD ?

        I've done blood test including sex hormones, cholesterol and urine. So hopefully they will give some sign or direction.

        Thanks once again.

        Yeah...well it's reversible but it might take a while, fortunately you didn't take them that long overall?
        How much time total, how many days approximately total did you take the serotonergic compounds, including the 5-HTP?

        Let me know how the hormone test pans out brother!

        SSRI & 5-HTP both are known to increase stress hormones when going above the moderate serum level, and can induce prolactin release as well....so it;s important to know...prolactin and cortisol and testosterone should all be checked, and probably E2 (estradiol,estrogen) as well...although usually estro usually goes too far down if anything..but you certainly don't want to raise it - just normalize cortisol and prolactin if that is the issue..if not....then and hormones are fine, then you need to work on the secondary nerves which would be as *I said , dopamine, histamine, glutamate etc..and nitric oxide.

        Comment


        • #5
          I went through my records trying find exact dates. I started 5HTP on 13 July and stopped it around 20 Aug - once per day for three weeks and then I took it twice per day for the next two weeks, it must be around 60-70 capsules in total. It looks like I took little bit more Priligy for that period - around 7-8 x 30mg on different days. The other supplement I took during that period was Maca root, once per day.

          I still remember that moment, literally it's like you pushed a button. I lost it and couldn't regain it anymore. I still can't get my head around how that's possible.

          Yes, when I visited my GP she said that we'll get my sex hormones tested and I asked for prolactin as well. I hope to be able to check them tomorrow although I'm not sure if I'll be able to obtain the exact values.

          I got inspired in a way by this book " 5-HTP: The Natural Way to Overcome Depression, Obesity and Insomnia" of Dr. Murray. I know people there had several cases but they were taking some 300/600/900 mg of 5HTP per day. I always thought that 100mg of 5HTP isn't that much after all.

          Thanks!

          Regards

          Comment


          • #6
            Originally posted by Neuromancer View Post
            I went through my records trying find exact dates. I started 5HTP on 13 July and stopped it around 20 Aug - once per day for three weeks and then I took it twice per day for the next two weeks, it must be around 60-70 capsules in total. It looks like I took little bit more Priligy for that period - around 7-8 x 30mg on different days. The other supplement I took during that period was Maca root, once per day.

            I still remember that moment, literally it's like you pushed a button. I lost it and couldn't regain it anymore. I still can't get my head around how that's possible.

            Yes, when I visited my GP she said that we'll get my sex hormones tested and I asked for prolactin as well. I hope to be able to check them tomorrow although I'm not sure if I'll be able to obtain the exact values.

            I got inspired in a way by this book " 5-HTP: The Natural Way to Overcome Depression, Obesity and Insomnia" of Dr. Murray. I know people there had several cases but they were taking some 300/600/900 mg of 5HTP per day. I always thought that 100mg of 5HTP isn't that much after all.

            Thanks!

            Regards

            Yes but you weren't depressed were you? Likely these doses also weren't coupled with an SSRI, in which case the side-effects wouldn't be as pronounced because there would be simply more serotonin available as opposed to an excess trapped into the synapse. When you combine two serotonergic acting compounds you double the amount of serotonin and this ends up depleting other important neurohormones and neurotransmitters.

            Also note that there is a huge difference between the doses that would be used for Pre-E and that for depression...usually depressed people have significantly lower serotonin metabolies..whereas with P.E you might have less serotonin - but not THAT low, not enough to parallel depressed subjects.
            corageon
            Banned
            Last edited by corageon; 10-22-2014, 04:12 PM.

            Comment


            • #7
              Agree.

              Corageon, I'm curious do you have an academic degree or you have read a lot of stuff on that topic. I got some of the basics from the book I mentioned and I was really amazed on how neurotransmitters work and mostly how important they are.

              Anyway, I do hope this is the root cause of my problem, can't think of anything else which happened during that period. I'm sorry if I ask the same question again but do you think this could have happened because of taking 5HTP and Priligy. I always thought that one has to abuse either supplement or take SSRIs for longer periods. The period I mixed them was little bit more than a month and here I'm now two months later without any change.

              I'll share the results once I've got them!

              Regards

              Comment


              • #8
                Originally posted by Neuromancer View Post
                Agree.

                Corageon, I'm curious do you have an academic degree or you have read a lot of stuff on that topic. I got some of the basics from the book I mentioned and I was really amazed on how neurotransmitters work and mostly how important they are.

                Anyway, I do hope this is the root cause of my problem, can't think of anything else which happened during that period. I'm sorry if I ask the same question again but do you think this could have happened because of taking 5HTP and Priligy. I always thought that one has to abuse either supplement or take SSRIs for longer periods. The period I mixed them was little bit more than a month and here I'm now two months later without any change.

                I'll share the results once I've got them!

                Regards

                Even a few weeks of SSRI use can downregulate receptors and cause sensitization changes. That being said, effects, including negative are generally more profound after 45-60 days. You certainly could have accelerated the pace by combining a potent serotonin precursor (5-HTP) plus the SSRI...in which case this flood of serotonin just managed to peak over that fine line and started inducing negative feedback, both upon itself and other neurohormones.

                Comment


                • #9
                  Now that's a mystery. Called the surgery today, they said my urine and blood tests are all NORMAL, prolactin, testosterone, other hormones are all normal. I'll go onsite tomorrow and try get the actual values although I'm not sure if they will give them to me. Meanwhile, any ideas ? When I mentioned to my GP that I was taking Priligy she didn't know what's that so I' not sure if she would be able to help me with anything else.

                  Corageon I wasn't taking SSRIs but Priligy, which is the same but they said it have immediate effect the same way your taking SSRIs in long term and lasts around 24 hrs. I took 7-8 pills during the period which makes 7-8 days of SSRIs along with 5HTP.

                  Thanks.

                  Comment


                  • #10
                    Originally posted by Neuromancer View Post
                    Now that's a mystery. Called the surgery today, they said my urine and blood tests are all NORMAL, prolactin, testosterone, other hormones are all normal. I'll go onsite tomorrow and try get the actual values although I'm not sure if they will give them to me. Meanwhile, any ideas ? When I mentioned to my GP that I was taking Priligy she didn't know what's that so I' not sure if she would be able to help me with anything else.


                    Corageon I wasn't taking SSRIs but Priligy, which is the same but they said it have immediate effect the same way your taking SSRIs in long term and lasts around 24 hrs. I took 7-8 pills during the period which makes 7-8 days of SSRIs along with 5HTP.

                    Thanks.
                    Get the exact values plus the ranges if you can. Doc's often have a habit of not even understanding the values themselves.

                    If indeed they are normal, doesn't mean they are IDEAL, or OPTIMAL.

                    Anyway, my recommendation when you find these out, would be a supplement such as "USPLabs PowerFULL"..either way your N.O producing nerves are depleted , so you have to act in the same fashion to get them going again.

                    You could start by eating more protein, taking l-histidine supplements, and looking into black indian shilajit or higher mountain shilajit....both of which are good products and natural n.o boosters/serotonin antagonists....

                    You may want to consider l-citrulline as well.

                    Lemme know when/if you get the values, it would certainly help - at the very least to get a better picture of the clockwork and tendencies of the drift, so to speak.

                    ~Corageon~

                    Comment


                    • #11
                      I'm already taking 2-3 scoops of Whey Protein Concentrate 82% per day. I'm eating more protein food in general as I'm trying to gain some weight.

                      For my big surprise I got all my results, here they are:
                      Testosterone - 21.5
                      Prolactin - 218
                      T4 - 12.6
                      TSH - 1.74
                      Prostate specific antigen - 1.3

                      Do you need any of the lipids, electrolytes or full blood count ?

                      Thanks!

                      Comment


                      • #12
                        Originally posted by Neuromancer View Post
                        I'm already taking 2-3 scoops of Whey Protein Concentrate 82% per day. I'm eating more protein food in general as I'm trying to gain some weight.

                        For my big surprise I got all my results, here they are:
                        Testosterone - 21.5
                        Prolactin - 218
                        T4 - 12.6
                        TSH - 1.74
                        Prostate specific antigen - 1.3

                        Do you need any of the lipids, electrolytes or full blood count ?

                        Thanks!
                        Ranges would be nice.

                        Comment


                        • #13
                          Excuse me:

                          Testosterone 21.5 10 - 30 nmol/L
                          Prolactin 218 73 - 407 mIU/L
                          T4 12.6 9 - 19 pmol/L
                          TSH 1.74 0.35 - 4.94 mu/L
                          Prostate specific antigen 1.3 < 2.10 ug/L

                          Comment


                          • #14
                            Originally posted by Neuromancer View Post
                            Excuse me:

                            Testosterone 21.5 10 - 30 nmol/L
                            Prolactin 218 73 - 407 mIU/L
                            T4 12.6 9 - 19 pmol/L
                            TSH 1.74 0.35 - 4.94 mu/L
                            Prostate specific antigen 1.3 < 2.10 ug/L
                            No estrogen test?

                            Prolactin is in the normal range, but it is far from in the ideal range.
                            Try to get your E2 level.

                            Comment


                            • #15
                              I'm afraid that's all I've got.

                              Oh dear that will take time. The first available appointment is for 12Nov same GP, I might get earlier date with another one from the same surgery. However it will then take another will for the results. (facepalm)

                              Comment

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