L-Histidine and folic acid. Possible key to unlocking massive growth.

**ino** · 05-26-2014

Originally Posted by ino

Do people with allergies have the 'correct' type of enhanced histamine level in their bodies as to the histamine discussed here for penis growth purposes?

Further, will the use of the mentioned histamine increasing supplement (L'Histidine) increase already existing allergies or trigger latent allergies?

I noticed how my question raised months ago was conveniently ignored, so I am going to answer the last part of it myself:

Two days ago I got stung at my underarm by burning nettle. I had experienced being stung years ago, so I thought it was no big deal. I was wrong. After less than half a minute I began feeling lightheaded. Further I became dizzy and noticed my pulse raising quickly. It was obvious to me that I was experiencing an allergic reaction. I swiftly got the bottle of tea tree oil, rubbed some on the inflicted skin area. Then I took an anti-histamine pill. (Luckily I still had anti-histamine pills at hand, as I had not been taking an anti-histamine pill for a couple of years.)

Before I got worse, I used a countdown timer, and held a finger at my wrist to check my pulse, and it was 98 beats pr. minute. I noticed that the tea tree oil worked on the skin, as the visual reaction was soon gone. Then I went to lie down. I continued to feel worse where I felt an increase of headache and nausea. I thought the worst symptoms would pass within ten or twenty minutes, like they usually do if I have eaten something I don't tolerate, (and especially since the tea tree oil had removed the skin rash), but not this time. The unpleasant symptoms continued for too long.

After perhaps an hour I decided calling ER. That after I began experiencing infrequent short-lasting throbbing pains in my head and chest as well as sporadically feeling spasms at my upper legs.) The receptionist said she would ask a doctor to call me back. A doctor called me back after half an hour, (yep, such is the efficient service in this oil and fish country), but by then my pulse had almost stabilised.

Since by then I was already feeling better, the talk with the doctor turned out to a little conversation about allergic reactions. To my specific question about burning nettle (I had to think about this thread promoting L'histidine when I asked her), she responded that it was not all uncommon to react severely on being stung by burning nettle - and then she meant serious reactions aside from the common local skin irritation. She had encountered several cases where people would develop serious asthma attacks after being stung by burning nettle.

ok, then to go further: We know that at least in the Western part of the world that the percent of people who develop allergies has increased immensely. It is not just a small percent anymore.

Therefore I believe it is a good idea to be cautious and consider potential ill-effect s before jumping onto trendy 'health remedies', like supplements that increase histamine levels in the blood. Believe me, you don't want to experience anaphylaxis.

Even if one isn't aware of having an allergy, an individual may anyway have an aggressive immune system, that only needs a little push to fully bloom into a radical bodily reaction. Many people who are allergic toward different substances know this: Some initial (as in first time) allergic reactions don't come sneaking, but hit down on a person like a bomb. After this initial allergic response, it is then visible on IgE antibody tests. But to repeat myself: The aggressive immune system has been lurking around for quite a time before the first symptoms would arise.

I still haven't read myself up on this whole thing about L'histidine, (and nettles) and its influence on people whose immune systems easily triggers an increase of histamine levels. But even without having done so, I think it is ok that I answer my own question raised month ago by a bold suggestion:

L'histidine supplements may indeed cause serious unwanted side effects on people whose immune systems have an inclination of reacting aggressively by producing an abundance of histamine in their bodies.

I am so happy that I only got stung at my underarm, and didn't whip my balls and arse with stinging nettle. Call me old fashioned, but I think I will go for some traditional kinky wet celery whipping instead:

**corageon** · 05-26-2014

Originally Posted by ino

I noticed how my question raised months ago was conveniently ignored, so I am going to answer the last part of it myself:

Two days ago I got stung at my underarm by burning nettle. I had experienced being stung years ago, so I thought it was no big deal. I was wrong. After less than half a minute I began feeling lightheaded. Further I became dizzy and noticed my pulse raising quickly. It was obvious to me that I was experiencing an allergic reaction. I swiftly got the bottle of tea tree oil, rubbed some on the inflicted skin area. Then I took an anti-histamine pill. (Luckily I still had anti-histamine pills at hand, as I had not been taking an anti-histamine pill for a couple of years.)

Before I got worse, I used a countdown timer, and held a finger at my wrist to check my pulse, and it was 98 beats pr. minute. I noticed that the tea tree oil worked on the skin, as the visual reaction was soon gone. Then I went to lie down. I continued to feel worse where I felt an increase of headache and nausea. I thought the worst symptoms would pass within ten or twenty minutes, like they usually do if I have eaten something I don't tolerate, (and especially since the tea tree oil had removed the skin rash), but not this time. The unpleasant symptoms continued for too long.

After perhaps an hour I decided calling ER. That after I began experiencing infrequent short-lasting throbbing pains in my head and chest as well as sporadically feeling spasms at my upper legs.) The receptionist said she would ask a doctor to call me back. A doctor called me back after half an hour, (yep, such is the efficient service in this oil and fish country), but by then my pulse had almost stabilised.

Since by then I was already feeling better, the talk with the doctor turned out to a little conversation about allergic reactions. To my specific question about burning nettle (I had to think about this thread promoting L'histidine when I asked her), she responded that it was not all uncommon to react severely on being stung by burning nettle - and then she meant serious reactions aside from the common local skin irritation. She had encountered several cases where people would develop serious asthma attacks after being stung by burning nettle.

ok, then to go further: We know that at least in the Western part of the world that the percent of people who develop allergies has increased immensely. It is not just a small percent anymore.

Therefore I believe it is a good idea to be cautious and consider potential ill-effect s before jumping onto trendy 'health remedies', like supplements that increase histamine levels in the blood. Believe me, you don't want to experience anaphylaxis.

Even if one isn't aware of having an allergy, an individual may anyway have an aggressive immune system, that only needs a little push to fully bloom into a radical bodily reaction. Many people who are allergic toward different substances know this: Some initial (as in first time) allergic reactions don't come sneaking, but hit down on a person like a bomb. After this initial allergic response, it is then visible on IgE antibody tests. But to repeat myself: The aggressive immune system has been lurking around for quite a time before the first symptoms would arise.

I still haven't read myself up on this whole thing about L'histidine, (and nettles) and its influence on people whose immune systems easily triggers an increase of histamine levels. But even without having done so, I think it is ok that I answer my own question raised month ago by a bold suggestion:

L'histidine supplements may indeed cause serious unwanted side effects on people whose immune systems have an inclination of reacting aggressively by producing an abundance of histamine in their bodies.

I am so happy that I only got stung at my underarm, and didn't whip my balls and arse with stinging nettle. Call me old fashioned, but I think I will go for some traditional kinky wet celery whipping instead:

Western, Modern civilization is also filled with estrogen-mimickers in the food and water, GMO's which cause histamine release in all the wrong area's, and more arsenic in the air of a popular city then ever was before - or can ever be breathed in a country world. Arsenic is pro-inflammatory as it accumulates, and disrupts normal Kreb cycles in the lungs; interfering with respiration and inducing histamine release. Yet everybody who has asthma and allergies is getting so used to stabbing themselves with an Epi-Pen and huffing their Albuterol inhaler.

This actually brings up an interesting point, Albuterol is an adrenergic steroid; it is a beta-agonist. It has been shown that the more you take in beta-agonists, the faster your natural beta-adrenergic receptors downregulate, so upon withdrawal of chronic albuterol use (or what could be "abuse"), should we be looking at the worsening of Asthma / Allergies altogether? Anything that increases cyclic AMP (like Beta-Agonist's) also decreases histamine release and allergies, therefore albuterol (while it's active) - inhibits histamine as well as bronchodilating - all through the same mechanism.

J Clin Invest. 2000 Jul;106(1):125-35.Albuterol-induced downregulation of Gsalpha accounts for pulmonary beta(2)-adrenoceptor desensitization in vivo.

Finney PA1, Belvisi MG, Donnelly LE, Chuang TT, Mak JC, Scorer C, Barnes PJ, Adcock IM, Giembycz MA.
Author information

Abstract

The aim of the present study was to develop a chronic in vivo model of pulmonary beta(2)-adrenoceptor desensitization and to elucidate the nature and molecular basis of this state. Subcutaneous infusion of rats with albuterol for 7 days compromised the ability of albuterol, given acutely, to protect against acetylcholine-induced bronchoconstriction. The bronchoprotective effect of prostaglandin E(2), but not *********, was also impaired, indicating that the desensitization was heterologous and that the primary defect in signaling was upstream of adenylyl cyclase. beta(2)-Adrenoceptor density was reduced in lung membranes harvested from albuterol-treated animals, and this was associated with impaired albuterol-induced cyclic adenosine monophosphate (cAMP) accumulation and activation of cAMP-dependent protein kinase ex vivo. Gsalpha expression was reduced in the lung and tracheae of albuterol-treated rats, and cholera toxin-induced cAMP accumulation was blunted. Chronic treatment of rats with albuterol also increased cAMP phosphodiesterase activity and G protein-coupled receptor kinase-2, but the extent to which these events contributed to beta(2)-adrenoceptor desensitization was unclear given that ********* was active in both groups of animals and that desensitization was heterologous. Collectively, these results indicate that albuterol effects heterologous desensitization of pulmonary Gs-coupled receptors in this model, with downregulation of Gsalpha representing a primary molecular etiology.

**corageon** · 07-27-2014

Originally Posted by smerc

High histamine can also cause itching.
Nettle also increases Free T by lowering SHBG, which would help as en erection enhancer.

I'm sure most people have histadelia while not even knowing it and also have a small penis.
Histadelia also has links (some say) to premature ejaculation.
I doubt there was any serotonin issue as high histamine in the brain works to lower dopamine which would increase serotonin levels, but some articles mention lowering of serotonin as well (which would play into PE problems).
These are neurochemicals so I doubt any histamine effect made it that far.

Just seems pretty far fetched.

High Histamine leads to lower serotonin by activation of H(3)R's (autoreceptors).....
Histamine H3 receptors inhibit serotonin release ... [J Neurosci. 2004] - PubMed - NCBI
Histamine H3 receptor-me... [Naunyn Schmiedebergs Arch Pharmacol. 1988] - PubMed - NCBI
Also lowers dopamine by the same receptor.
Histamine inhibits dopamine release in the mouse striatum via presynaptic H3 receptors - Springer

It would appear that most of the negative sides of histamine come from the activation of H(3)R's and H(4)R's.
Including itching and inflammation by H(4)'s.
Hence why experimental chemicals like Thioperamide have been used to treat inflammation, itching and asthma.

Also - in theory, Histamine H(1)R's may reduce serotonin efflux by mean and persistent activation of Calcium Channels.

Effects of histamine, H1- and H2-recept... [J Pharmacol Exp Ther. 1983] - PubMed - NCBI

Histamine-induced depression of serotoninerg... [Eur J Pharmacol. 1984] - PubMed - NCBI

Histamine H1 receptors in rat dorsal raphe nucleus... [Brain Res. 2002] - PubMed - NCBI

**corageon** · 08-16-2014

This may be what everyone is looking for in regards to this.
amxworkshop - My Book on Histamine

**Revolved** · 09-05-2014

Any updates on people who have tried this? What would be a "safe" amount to take as a daily supplement without fear of some of the possible negative side effects that have been pointed out?

**mastodon** · 09-07-2014

actually i just smiled when iread this article at first page. lets talk clear, histidine is just an aminoacide that we can take from diets with proteins. folic acide is knows as a vitamine, you can take it from vegetables and some fruits. now i have to say histamine and other mediators are not depended on our diets amount. actually you take these from you regular diets. your body produces mediators like histamine at necessary situation like inflamation or nerve stimulation etc. we do PE and need extra nutritions. lets talk about what penile enlargement needs. he need all essential foods and nutritions like aminoacides, minerals, oil acides, vitamines and hormones which is managing size and stamina. so ihave to say l-arg (as most of us know) that picks up growth hormone and cGMP mediator (manage erections). but first of all we have to take "good" diet including these essentials and antioxidans like vit E and C. the rest of it you are doing already..
good large days

**corageon** · 09-08-2014

Originally Posted by Revolved

Any updates on people who have tried this? What would be a "safe" amount to take as a daily supplement without fear of some of the possible negative side effects that have been pointed out?

I did try the histamine boosting cocktail a few times; including H3R antagonists = notable euphoria, enhanced intellectual ability and much better pumps all for all - appetite went right out the window though...that's not surprising given that histamine is the most potent natural appetite suppressant besides serotonin and adrenaline. Also my libido is usually pretty high, the histamine shit is no joke because it sent it to ObsessionMode.