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Demystifying medical treatment for premature ejaculation
DISCLAIMER: I am not a doctor, neither a professional in neurology, i just put around 200 hours of research into this and want to make the topic easier for others so they do understand better what they want to put into their body. I also want to add that this area still remains one that has to be dived deeper into so i am not promising anybody the absolute truth here.
This is also not a post that wants to dismiss effort made in the forum on other topics such as the mechanic function of Reverse Kegels that may help some people.
Furthermore it is not a post that is supposed to excuse your own mindset with your pre-existing genetic or lifestyle conditions. You can conciously work on your mindset, it is a powerfull tool in your overall appearance and appraoch to the world.
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Before i want to talk about premature ejaculation itself, i want to show you guys how our body creates stimulus. Stimulus is not restricted to only touching things, there are other senses like smell, taste, visuals, audios.
Our body needs a way to process every aspect of stimuli around us. We do that with nerves. To be more precise, we do that with Neurons. Neurons are nerve cells that carry information between the brain and other parts of the body.
AfmsJ.jpg
Many of these Neurons chained together are the way stimulus can be carried around through your body via electric signals. Neurons send the signal from one neuron to the other using neurotransmitters between the dendrite and the axon terminal
Synapse.jpg
Sex in all its various facades is nothing else than strong stimuli and biology at work carrying hormones through your body. The glans with the amount of the nerve endings in it is one of the most sensitive parts of the body overall.
948f1debcd9e4ae596f3ec053dd06402.jpg
Having sex, your glans will be stimulated no matter the activity. But you have to remind yourself mechanical stimulus is not the only way stimuli can be processed, visual, audios and smell are also part of that.
That said, let’s dive deeper into neurotransmitters. They can be categorized into two categories. Excitatory and inhibitory neurotransmitters.
A neurotransmitter can influence the function of a neuron through a remarkable number of mechanisms. In its direct actions in influencing a neuron’s electrical excitability, however, a neurotransmitter acts in only one of two ways: excitatory or inhibitory. A neurotransmitter influences trans-membrane ion flow either to increase (excitatory) or to decrease (inhibitory) the probability that the cell with which it comes in contact will produce an action potential. Thus, despite the wide variety of synapses, they all convey messages of only these two types, and they are labeled as such. Each type has a different appearance and is located on different parts of the neurons under its influence.
neurotransmitters.jpg
While you may have rightfully heard and influenced some of these neurotransmitters, i want to focus on the probably two most important for premature ejaculation which are GABA and Glutamate. GABA being one of the main inhibitory neurotransmitters, Glutamate being one of the main excitatory neurotransmitters.
Now you can simply put it like this: The more GABA the more stimulation a neuron needs for its signal to be fired to the next neuron. GABA and glutamate play against each other that way and also influence other neurotransmitters. Furthermore there are other things to put in perspective, for example you have to have a normal Serotonin-level for GABA to work properly,… too much for that post.
So how does this influence premature ejaculation you might ask?
I give you a few examples:
Alcohol works in various ways on ones hormones. It is a depressant but upon intake, it produces GABA and blocks receptors for Glutamate (NMDA-Antagonist). This way, your needed action potential is higher, you feel less stimulation, you last longer while having sex, you are less reactive…
Alcoholism however, that means repeated excess intake of alcohol makes the body produce more GABA receptors, because the „usual“ ones are permanently blocked. In the end you end up with even more receptors that worsen your symtpoms
Phenibut is a Anxiolytikum that functions as GABA-Agonist. As a sequel it binds to GABA receptors and prevents overstimulation by excess glutamate thus making you last longer.
You see there is an undeniable corelation between GABA/Glutamate interaction and ejaculation control. I know you are already in your mind thinking „How can i increase GABA right now?“. This is where it gets complex. I give you a quick overview on why it is hard to increase GABA and some potential things that can help increasing it.
The first point are genetic mutations that inhibit you forming as much GABA as you would need to remain calm. It is the goddamn genetics again. There are several ways this can take actions.
For example, i have seen a post on this forum with a guy that had a medical appointment and cured his premature ejaculation by excess intake of B6 and Zinc.
https://www.pegym.com/forums/prematu...pplements.html
He had/has what is called Pyroluria which results in a deficiency in B6 and Zinc which are crucial for producing GABA in your body.
I just leave this here as an example but there are more preexisting genetic conditions that influence this.
The second point is chronic stress.
It is a major contributing factor to depletion of GABA and other inhibitory neurotransmitters. High levels of inhibitory neurotransmitters like gamma-aminobutyric acid and serotonin are needed to modulate the stress response system. They help the mind and body return to the parasympathetic state when the stressful event is over. If the stressful event is never over, then they are called upon repeatedly and over time this will drain their levels. Therefore, managing chronic stress is a vital element for the GABA and glutamate balance.
Childhood abuse or trauma alters GABA receptors, resulting in less GABA function, and this is carried with the survivor into adulthood. Survivors of abuse also have lower levels of serotonin and dopamine.
The third point is excess glutamate, for example by eating too much foods with excitotoxins that endorse production of it.
Problems with increasing GABA:
First point: GABA-supplementation can not pass the blood-barrier, because the compound is too big to do so which results in quite nothing in most cases. So you often want to supplement precursors to GABA, so it can then form into GABA. This is unfortunately not the case if your genetics are not in the same team.
gaba.jpg
As you see in this graphic the precursor to GABA is actually Glutamate. Your brain is supposed to transform excess glutamate into GABA. There are several factors that can contribute to why your system can’t properly form GABA including genetics. Also, if you take things like Phenibut in too much excess, your body depletes production which leads to lower GABA, so you have to be carefull.
Things that could possibly help to increase your GABA production are:
NDMA-Antagonists are not GABA-producers, they just block glutamate receptors! It is not black and white. For example taurin also could have negative effects. It is trial and error right there.
Thank you for reading, i am open for additional input, knowledge and criticism that could contribute to the knowledgebase for premature ejaculation
This is also not a post that wants to dismiss effort made in the forum on other topics such as the mechanic function of Reverse Kegels that may help some people.
Furthermore it is not a post that is supposed to excuse your own mindset with your pre-existing genetic or lifestyle conditions. You can conciously work on your mindset, it is a powerfull tool in your overall appearance and appraoch to the world.
----------------------------------------------------------------
Before i want to talk about premature ejaculation itself, i want to show you guys how our body creates stimulus. Stimulus is not restricted to only touching things, there are other senses like smell, taste, visuals, audios.
Our body needs a way to process every aspect of stimuli around us. We do that with nerves. To be more precise, we do that with Neurons. Neurons are nerve cells that carry information between the brain and other parts of the body.
AfmsJ.jpg
Many of these Neurons chained together are the way stimulus can be carried around through your body via electric signals. Neurons send the signal from one neuron to the other using neurotransmitters between the dendrite and the axon terminal
Synapse.jpg
Sex in all its various facades is nothing else than strong stimuli and biology at work carrying hormones through your body. The glans with the amount of the nerve endings in it is one of the most sensitive parts of the body overall.
948f1debcd9e4ae596f3ec053dd06402.jpg
Having sex, your glans will be stimulated no matter the activity. But you have to remind yourself mechanical stimulus is not the only way stimuli can be processed, visual, audios and smell are also part of that.
That said, let’s dive deeper into neurotransmitters. They can be categorized into two categories. Excitatory and inhibitory neurotransmitters.
A neurotransmitter can influence the function of a neuron through a remarkable number of mechanisms. In its direct actions in influencing a neuron’s electrical excitability, however, a neurotransmitter acts in only one of two ways: excitatory or inhibitory. A neurotransmitter influences trans-membrane ion flow either to increase (excitatory) or to decrease (inhibitory) the probability that the cell with which it comes in contact will produce an action potential. Thus, despite the wide variety of synapses, they all convey messages of only these two types, and they are labeled as such. Each type has a different appearance and is located on different parts of the neurons under its influence.
neurotransmitters.jpg
While you may have rightfully heard and influenced some of these neurotransmitters, i want to focus on the probably two most important for premature ejaculation which are GABA and Glutamate. GABA being one of the main inhibitory neurotransmitters, Glutamate being one of the main excitatory neurotransmitters.
Now you can simply put it like this: The more GABA the more stimulation a neuron needs for its signal to be fired to the next neuron. GABA and glutamate play against each other that way and also influence other neurotransmitters. Furthermore there are other things to put in perspective, for example you have to have a normal Serotonin-level for GABA to work properly,… too much for that post.
So how does this influence premature ejaculation you might ask?
I give you a few examples:
- Alcohol
Alcohol works in various ways on ones hormones. It is a depressant but upon intake, it produces GABA and blocks receptors for Glutamate (NMDA-Antagonist). This way, your needed action potential is higher, you feel less stimulation, you last longer while having sex, you are less reactive…
Alcoholism however, that means repeated excess intake of alcohol makes the body produce more GABA receptors, because the „usual“ ones are permanently blocked. In the end you end up with even more receptors that worsen your symtpoms
- Phenibut
Phenibut is a Anxiolytikum that functions as GABA-Agonist. As a sequel it binds to GABA receptors and prevents overstimulation by excess glutamate thus making you last longer.
- Dextrometorphan, mainly found in cough-syrup also works als NMDA Antagonist.
- SSRIs were long time a question mark on prolonging Intravaginal ejaculation latency for many scientists. It is found out that these also work as NDMA-Antagonists
You see there is an undeniable corelation between GABA/Glutamate interaction and ejaculation control. I know you are already in your mind thinking „How can i increase GABA right now?“. This is where it gets complex. I give you a quick overview on why it is hard to increase GABA and some potential things that can help increasing it.
The first point are genetic mutations that inhibit you forming as much GABA as you would need to remain calm. It is the goddamn genetics again. There are several ways this can take actions.
For example, i have seen a post on this forum with a guy that had a medical appointment and cured his premature ejaculation by excess intake of B6 and Zinc.
https://www.pegym.com/forums/prematu...pplements.html
He had/has what is called Pyroluria which results in a deficiency in B6 and Zinc which are crucial for producing GABA in your body.
I just leave this here as an example but there are more preexisting genetic conditions that influence this.
The second point is chronic stress.
It is a major contributing factor to depletion of GABA and other inhibitory neurotransmitters. High levels of inhibitory neurotransmitters like gamma-aminobutyric acid and serotonin are needed to modulate the stress response system. They help the mind and body return to the parasympathetic state when the stressful event is over. If the stressful event is never over, then they are called upon repeatedly and over time this will drain their levels. Therefore, managing chronic stress is a vital element for the GABA and glutamate balance.
Childhood abuse or trauma alters GABA receptors, resulting in less GABA function, and this is carried with the survivor into adulthood. Survivors of abuse also have lower levels of serotonin and dopamine.
The third point is excess glutamate, for example by eating too much foods with excitotoxins that endorse production of it.
Problems with increasing GABA:
First point: GABA-supplementation can not pass the blood-barrier, because the compound is too big to do so which results in quite nothing in most cases. So you often want to supplement precursors to GABA, so it can then form into GABA. This is unfortunately not the case if your genetics are not in the same team.
gaba.jpg
As you see in this graphic the precursor to GABA is actually Glutamate. Your brain is supposed to transform excess glutamate into GABA. There are several factors that can contribute to why your system can’t properly form GABA including genetics. Also, if you take things like Phenibut in too much excess, your body depletes production which leads to lower GABA, so you have to be carefull.
Things that could possibly help to increase your GABA production are:
- Staying away from stressfull interactions as much as possible
- Exercise
- Meditation ( and Yoga)
- Trying to actively influencing your mindset as this can be a powerfull tool against learned patterns
- Supplements
- L-Glutamine (precursor for Glutamate)
- 5-htp (translates into serotonin but there are complex chains that also increase GABA, see sufferers that help themeselfes with melatonin)
- Taurin which can act as a neuromodulator and as a sequel may be able to endorse production
- B6 and Zinc if you suffer Pyroluria
NDMA-Antagonists are not GABA-producers, they just block glutamate receptors! It is not black and white. For example taurin also could have negative effects. It is trial and error right there.
Thank you for reading, i am open for additional input, knowledge and criticism that could contribute to the knowledgebase for premature ejaculation
Admin of the Month Mar 2015
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